Browsing by Author "González, Sergio"

Now showing items 1-16 of 16

    • Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of ... 
      González, Sergio; Aguilera, Sergio; Alliende, Cecilia; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Herrera Cisterna, Luisa; Molina, Claudio; Hermoso Ramello, Marcela; Ewert, Patricia; Brito, Mónica; Romo, Rafael; Leyton Martínez, Cecilia; Pérez, Paola; González Burgos, María Julieta (2011-04)
      Objective. Acinar cells in the salivary glands of patients with Sjo¨gren’s syndrome (SS) display severe alterations in anchorage to the basal lamina. Bioinformatics analysis of the BP230 gene sequence has revealed the ...
    • Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and ... 
      Lagos, Carolina; Carvajal, Patricia; Castro, Isabel; Jara, Daniela; González, Sergio; Aguilera, Sergio; Barrera, María José; Quest, Andrew F. G.; Bahamondes, Verónica; Molina, Claudio; Urzúa, Ulises; Hermoso Ramello, Marcela; Leyton, Cecilia; González Burgos, María Julieta (Academic Press Inc., 2018)
      © 2018 Elsevier Inc.Here, we determined the 5-hydroxymethylcytosine (5hmC), 5-methylcytosine (5mC), Ten Eleven Translocation (TETs), and DNA methyltransferases (DNMTs) levels in epithelial and inflammatory cells of labial ...
    • Changes in Rab3D Expression and Distribution in the Acini of Sjogren's Syndrome Patients Are Associated ... 
      Bahamondes, Verónica; Albornoz, Amelina; Aguilera, Sergio; Alliende, Cecilia; Molina, Claudio; Castro, Isabel; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Barrera, María José; González, Sergio; Sánchez, Marianela; Härtel, Steffen; Hermoso Ramello, Marcela; Leyton Martínez, Cecilia; González Burgos, María Julieta (WILEY-BLACKWELL, 2011-10)
      Objective. Oral and ocular dryness are frequent and serious symptoms of Sjogren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
    • Color Doppler Sonography of Cutaneous Juvenile Xanthogranuloma With Clinical and Histologic Correlations 
      Niklitschek, Sergio; Niklitschek, Ian; González, Sergio; Wortsman, Ximena (Amer Inst Ultrasound Medicine, 2016)
    • Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in ... 
      Castro, Isabel; Aguilera, Sergio; Brockhausen, Inka; Alliende, Cecilia; Quest, Andrew F. G.; Molina, Claudio; Urzúa Tobar, Ulises; Mandel, Ulla; Bahamondes, Verónica; Barrera, María José; Sánchez, Marianela; González, Sergio; Hermoso Ramello, Marcela; Leyton Martínez, Cecilia; González Burgos, María Julieta (Oxford University Press, 2012)
      Objectives. To determine the expression and enzymatic activities of sulphotransferases involved in mucin hyposulphation in labial salivary glands (LSGs) from SS patients and to correlate sulphotransferase activity with ...
    • Endoplasmic reticulum stress in autoimmune diseases: Can altered protein quality control and/or unfolded ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; González, Sergio; Carvajal, Patricia; Molina, Claudio; Hermoso, Marcela A.; González, María Julieta (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. For many years, researchers in the field of autoimmunity have focused on the role of the immune components in the etiopathogenesis of autoimmune diseases. However, some studies have demonstrated the ...
    • Generación de Diálogo Chile-Perú / Perú-Chile. Documento 2: Aspectos históricos 
      Fernandois, Joaquín; Parodi, Daniel; Zapata, Antonio; González, Sergio (Konrad Adenauer Stiftung; Pontificia Universidad Católica del Perú, Instituto de Estudios Internacionales (IDEI); Universidad de Chile. Instituto de Estudios Internacionales, 2011)
    • Lobectomía en ratas. Modelo quirúrgico experimental. Resultados en la densidad alveolar 
      Martínez, Mónica; Velázquez, Nelson; Flores, Emilio; Navarrete, Andrés; Zúñiga, Felipe; Zitko, Pedro; García, Cristián; González, Sergio; Zúñiga, Sergio (2014)
      Introducción: En la literatura está documentado que diferentes mamíferos tienen la capacidad de creci¬miento compensatorio post resección pulmonar parcial. Objetivo: Crear un modelo quirúrgico de lobectomía en ratas, ...
    • Mechanotransduction and epigenetic control in autoimmune diseases 
      González, Sergio; Aguilera, Sergio; Urzúa Tobar, Ulises; Quest, Andrew F. G.; Molina, Claudio; Alliende, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Elsevier, 2011)
      Differentiation of epithelial cells is required to define tissue architecture and appropriate function of these cells is associated with a specific pattern of gene expression. DNA methylation, post-translational modification ...
    • Novel and recurrent COL7A1 mutations in Chilean patients with dystrophic epidermolysis bullosa 
      Rodíguez, Fernando A.; Gana, María José; Yubero, María Joao; Zillmann Geerdts, Gisela del Carmen; Krämer Strenger, Susanne; Catalán, Javiera; Rubio Astudillo, Julia; González, Sergio; Liu, Lu; Ozoemena, Linda; Mellerio, Jemima M.; McGrath, John A.; Palisson, Francis; Conget, Paulette (Elsevier, 2012-02)
    • Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren's ... 
      Barrera, María José; Aguilera, Sergio; Castro, Isabel; Cortés Araya, Juan Eliecer; Bahamondes Lorca, Verónica; Quest, Andrew F. G.; Molina, Claudio; González, Sergio; Hermoso Ramello, Marcela; Urzúa Tobar, Ulises; Leyton, Cecilia; González Burgos, María Julieta (Elsevier, 2016)
      Salivary gland (SG) acinar-cells are susceptible to endoplasmic reticulum (ER) stress related to their secretory activity and the complexity of synthesized secretory products. SGs of Sji5gren's syndrome patients (SS)-patients ...
    • Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular ... 
      Barrera, María José; Aguilera, Sergio; Veerman, Enno; Quest, Andrew F. G.; Díaz Jiménez, David; Urzúa Tobar, Ulises; Cortés Araya, Juan Eliecer; González, Sergio; Castro, Isabel; Molina, Claudio; Bahamondes, Verónica; Leyton, Cecilia; Hermoso Ramello, Marcela; González Burgos, María Julieta (Oxford Univ Press, 2015)
      Objectives. A hallmark characteristic of SS patients is the ectopic presence of the mucins MUC5B and MUC7 in the extracellular matrix of salivary glands that have lost apical basolateral acinar-cell polarity. This study ...
    • Small RNA expression profiling reveals hsa-miR-181d-5p downregulation associated with TNF-α overexpression ... 
      Castro Masso, Isabel Verónica; Carvajal Garcés, Patricia Alejandra; Jara, Daniela; Aguilera, Sergio; Heathcote Pérez, Benjamín Norman; Barrera, María José; Aliaga Tobar, Víctor Manuel; Maracaja Coutinho, Vinicius; Urzúa Tobar, Ulises; Quest, Andrew Frederick Geoffery; González, Sergio; Claudio, Molina; Hermoso, Marcela Alejandra; González Burgos, María Julieta (Frontiers Media, 2022)
      MicroRNAs (miRNAs) are small non-coding RNAs (sRNA), that alter gene expression by binding to target messenger RNAs (mRNAs) and repressing translation. Dysregulated miRNA expression has been implicated in the pathogenesis ...
    • Spatial variability of near-surface temperature over the coastal mountains in southern Chile (38°S) 
      González, Sergio; Garreaud Salazar, René (Springer-Verlag Wien, 2019)
      The spatial distribution of the near-surface air temperature over a coastal mountain range in southern Chile [Nahuelbuta Mountains (NM), 38°S, maximum height 1300-m ASL] is investigated using in situ measurements, ...
    • Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from ... 
      Cortés, Juan; Hidalgo, Jorge; Aguilera, Sergio; Castro, Isabel; Brito, Mónica; Urra, Hery; Pérez, Paola; Barrera, María José; Carvajal, Patricia; Urzúa, Ulises; González, Sergio; Molina, Claudio; Bahamondes, Verónica; Hermoso, Marcela; González, María Julieta (Academic Press, 2019)
      Sjögren's syndrome (SS) is an autoimmune exocrinopathy associated with severe secretory alterations by disruption of the glandular architecture integrity, which is fundamental for a correct function and localization of the ...
    • Type I interferon dependent hsa-miR-145-5p downregulation modulates MUC1 and TLR4 overexpression in salivary ... 
      Jara, Daniela; Carvajal, Patricia; Castro Masso, Isabel Verónica; Barrera, María José; Aguilera, Sergio; González, Sergio; Molina, Claudio; Hermoso, Marcela Alejandra; González Burgos, María Antonieta (Frontiers Media, 2021)
      Sjögren’s syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and is characterized by overactivation of the type I interferon (IFN) pathway. Type I IFNs can decrease the levels of hsa-miR-145-5p, ...